Posted by undopaminergic on December 9, 2022, at 8:14:21
I finally initiated vortioxetine today at 5 mg/day.
I've noticed a definite, but still modest, effect. I feel a slight improvement in mood, cognition, and attention. I am less certain about a stimulant-like effect with regard to amelioration of apathy.
I've tried to find research on the effects of vortioxetine on dopamine. I did not find anything intriguing, only comments in passing about an increase in the release of dopamine and several other neurotransmitters (at least serotonin, noradrenaline, acetylcholine, and histamine).
I found this interesting citation:
https://pubmed.ncbi.nlm.nih.gov/26209859/
--quote--
... Antidepressants had a positive effect on psychomotor speed ...
Of note, after removal of vortioxetine from the analysis, statistical
significance was lost for psychomotor speed.
--end-quote--All in all the trial is off to a good start.
poster:undopaminergic
thread:1121240
URL: http://www.dr-bob.org/babble/20220917/msgs/1121240.html