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Re: Finally trying vortioxetine -- initial impressions

Posted by Jay2112 on December 17, 2022, at 17:52:29

In reply to Re: Finally trying vortioxetine -- initial impressions NKP, posted by SLS on December 17, 2022, at 15:40:49

> > > > Hi UD:
> > > >
> > > > I too take vortioxetine, and find the nausea is very least when I take it later in the day/evening, with food. Ginger also helps. I have read the nausea may be from the cholinergic effects, which are a positive aspect of this drug. Ginger is an excellent anti-nauseant.
> > > >
> > >
> > > Hi, Jay.
> > >
> > > Is that PRO-cholinergic? How does that work?
> > >
> > > Thanks.
> > >
> > >
> > > - Scott
> > >
> > >
> >
> > Are there other antidepressants that are pro-cholinergic too? Might this account for the side-effect of excessive sweating that many antidepressants have?
>
> That's a great question. I never looked into it. The first antidepressant I ever tried
>
>
>
> No. It is anticholinergic drugs (muscarinic receptor antagonists) that produce increased sweating.
>
>
> - Pro-cholinergic drugs are depressogengic (pilocarpine).
>
> - Anti-cholinergic drugs are antidepressant (scopolamine).
>
> Scopolamine has been studied as a rapid-acting antidepressant. I don't see much about it anymore. However. I haven't been following it.
>
>
> - Scott
>
>
>
>
>

I have found amitriptyline, at very high doses, to seem to be similar to scopolamine. Both are strong anti-cholinergic's. I found 200mg's of amitriptyline to be a)powerful sleep inducer b)powerful anti-anxiety. Amitriptyline doesn't seem to have the overpowering, akathisia-inducing effects of SSRI's.

Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:Jay2112 thread:1121240
URL: http://www.dr-bob.org/babble/20220917/msgs/1121275.html