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Re: Finally trying vortioxetine -- initial impressions

Posted by undopaminergic on December 16, 2022, at 10:19:41

In reply to Re: Finally trying vortioxetine -- initial impressions undopaminergic, posted by SLS on December 10, 2022, at 8:11:59

> Hi again, UD .

Hi again SLS!

> I told my main research doctor at the NIH that I wanted to go to medical school. He was quite emphatic in recommending that I don't. He said that it would be too much stress on the brain. This is particularly true of not having a regular circadian rhythm as one does their internship in a hospital. The hours shift all the time. All of this combined would almost guarantee that I suffer a medication-breakthrough relapse. Remember, if you achieve remission, it will be under the conditions that you achieved it.

I have no regular circadian rhythm when I'm left to my own devices and let my sleep-wake cycle be decided by how sleepy or how wakeful I'm feeling. When I'm using stimulants heavily, I'm up for days on end -- I pretty much make it a lifestyle. I think this may be regarded as a stereotypy.

> I am glad that your initial reaction was an almost instant improvement in depression. This is what the National Institutes of Health (NIH) called a "blip". They considered a TEMPORARY blip early during the course of a drug trial to be predictive of eventual treatment success - although not necessarily remission.
> Keep taking your antidepressants if this blip at the beginning comes and goes. You might have to wait 4-6 weeks to see the beginnings of a true clinical response.

It's been blipping several times a day so far.





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