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Re: Finally trying vortioxetine -- initial impressions SLS

Posted by undopaminergic on December 28, 2022, at 16:11:51

In reply to Re: Finally trying vortioxetine -- initial impressions undopaminergic, posted by SLS on December 28, 2022, at 14:27:42

> Hi, UD.


> I had been following cariprazine for a few years while it was under development. I really wanted the the increased ratio of dopamine D3/D2 receptor binding. It hurt more than it helped for my bipolar depression.
> For me, the following antipsychotics produced an improvement in depression:
> risperidone
> aripiprazole
> asenapine
> olanzapine

Risperidone was the worst I've tried, but that was in a different era (beginning of 2000s decade). I might react differently to it now.

Aripiprazole was without benefit, but stimulated salivation and induced an (eye) accommodation disorder. I had better luck with dopamine pure agonists (pramipexole), but the initial (and unique) anti-anhedonic effect was quickly lost, and I did not try high doses.

Asenapine is one I'd like to try.

Olanzapine has sometimes had a short lived beneficial (less apathy) effect at first. Otherwise it makes me tired and has a tendency to stimulate appetite.

I've also tried other antipsychotics. Sulpiride is the most impressive of them. At first (at low doses) it was a stronger stimulant than methylphenidate. This effect was quickly lost, and did not come back after a considerable period of abstinence.





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