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Re: Finally trying vortioxetine -- initial impressions undopaminergic

Posted by SLS on December 28, 2022, at 17:01:55

In reply to Re: Finally trying vortioxetine -- initial impressions SLS, posted by undopaminergic on December 28, 2022, at 16:11:51

Amisulpride *might* be more effective for depression than sulpiride. Its anti-dysthymic properties are supposedly well-established. Like sulpiride, low dosages effect more of a pro-dopaminergic effect than high dosages. This is likely because presynaptic autoreceptors have a higher binding affinity to dopamine than postsynaptic receptors do. This yields a net increase in the release of dopamine. The dosages that I have seen quoted most often to treat dysthymia and depression are 25-50 mg/day. Much higher dosages of amisulpride are needed to treat schizoid or psychotic conditions. Since you have already tried sulpiride with inadequate results, I doubt it makes sense to try amisulpride at this juncture.

What about adrafinil? I believe that's available in Europe. People who tried both adrafinil and modafinil here on Psycho-Babble preferred adrafinil, and were willing to import it.

My first dose of sulpiride made me feel great. However, the improvement dissipated within hours and never returned, despite continued treatment.

I am unclear as to what condition(s) you are dealing with. Would schizoaffective disorder be an applicable term?

I recommend that people make a list of what drugs made them feel better, regardless of magnitude or duration. Then make a list of those drugs that made you feel significantly worse where the worsening did not dissipate quickly. Which drugs were totally inert, and that you would not mind revisiting. Then you can look for commonalities, synergisms, and complementarity between drugs. You can choose which agents to combine based upon your previous experiences with them empirically and what you know about their pharmacology. I usually take into consideration empirical observations first and pharmacology later in the selection process.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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