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Re: Finally trying vortioxetine -- initial impressions undopaminergic

Posted by SLS on December 10, 2022, at 8:11:59

In reply to Finally trying vortioxetine -- initial impressions, posted by undopaminergic on December 9, 2022, at 8:14:21

Hi again, UD .

> I finally initiated vortioxetine today at 5 mg/day.

> I've noticed a definite, but still modest, effect. I feel a slight improvement in mood, cognition, and attention. I am less certain about a stimulant-like effect with regard to amelioration of apathy.

I've tried to find research on the effects of vortioxetine on dopamine. I did not find anything intriguing, only comments in passing about an increase in the release of dopamine and several other neurotransmitters (at least serotonin, noradrenaline, acetylcholine, and histamine).
> I found this interesting citation:


> --quote--
... Antidepressants had a positive effect on psychomotor speed ...
Of note, after removal of vortioxetine from the analysis, statistical
significance was lost for psychomotor speed.


That is an EXCELLENT article, and it absolutely describes what happens to me as I approach remission. However, I might relapse by the time I finish typing this sentence. Nothing is guaranteed to work forever. Nardil often stops working after 10 years of remission. It appears as being spontaneous. However, this might actually be a result of stressing the brain too much. It is CRITICAL that one remove as much psychosocial stress and anxiety as much as possible. This often requires psychotherapy. Otherwise, one may experience a "medication breakthrough" relapse.

I told my main research doctor at the NIH that I wanted to go to medical school. He was quite emphatic in recommending that I don't. He said that it would be too much stress on the brain. This is particularly true of not having a regular circadian rhythm as one does their internship in a hospital. The hours shift all the time. All of this combined would almost guarantee that I suffer a medication-breakthrough relapse. Remember, if you achieve remission, it will be under the conditions that you achieved it.


> All in all the trial is off to a good start.


I am glad that your initial reaction was an almost instant improvement in depression. This is what the National Institutes of Health (NIH) called a "blip". They considered a TEMPORARY blip early during the course of a drug trial to be predictive of eventual treatment success - although not necessarily remission.

Keep taking your antidepressants if this blip at the beginning comes and goes. You might have to wait 4-6 weeks to see the beginnings of a true clinical response.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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