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Re: Finally trying vortioxetine -- initial impressions

Posted by undopaminergic on December 28, 2022, at 10:52:39

In reply to Re: Finally trying vortioxetine -- initial impressions, posted by SLS on December 27, 2022, at 22:25:07

> Around the same time vortioxetine was approved, there was an increased interest in the properties of the 5-HT7 receptor as a site to exploit to treat depression as an antagonist. To my knowledge, vortioxetine is the only antidepressant possessing this property. Another drug with this property is lurasidone, an antipsychotic. Lurasidone has been advertised as a treatment of bipolar II depression. However, I have not seen any great successes with lurasidone for this indication. I dont know how well it has proven to treat schizophrenia.

I tried lurasidone, and it was a disappointment. It didn't have any notable adverse effects though.

> People with depression often report being able to think more clearly (improved cognition) with vortioxetine before an improvement in depression occurs. I dont know why.

Yes. It seems to be related to the action of 5-HT3 agonism.

> Has anyone spoken about lumateperone (Caplyta) for depression here?

It does not seem to be available in Europe.





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