Posted by desolationrower on December 17, 2008, at 23:01:12
In reply to Re: Treatment Resistant (Refractory) Depression, posted by CaptainAmerica1967 on December 17, 2008, at 21:11:43
If you haven't tried buprenorphine or lowdose naltrexone, i think that would be the obvious thing. I think they either could be taken with current regimine.
Dextromethorphan has some similarities to ketamine. It has strong affinity for the SERT (i think, info is hard to come by) so definatly not something you can take with parnate. I think it has some specific dopaminergic activity as well, and sigma. Of course, i have no idea if this would be benefical long-term, but it is another easily avilible uncompetitive NMDA antagonist
Did you try the memantine with the current drugs, and did you take at least 40mg? It seems to be more effective at higher doses. I'm asking again as some of the studies show subtherapeutic mem+tca or other AD results in full antidepressant effect.
Also, have you tried adding NAC to your current drugs.
Scott, you've mentioned modafinil+MAOI as synergistic, any particular reason? I haven't noticed any strong effect from adrafinil with parnate and my other stuff, n=1. Oh and wherever it was mentioned, i don't know about specific Li/Glu interaction or PCK. I believe it increases glu uptake chronically. Given Mgs role in the NMDA receptor, i'd think it interacts in some fashion.