Posted by CaptainAmerica1967 on December 16, 2008, at 20:39:02
In reply to Re: Treatment Resistant (Refractory) Depression » CaptainAmerica1967, posted by YOGI BRONX on December 16, 2008, at 16:23:03
Hi YOGI,
Thanks for your input and experience.
Yes, I've tried Ixel (milnacipran)and have researched it extensively, but like most other meds except the MAOI (type A's), milnacipran was a failure. It may be approved (clinicaltrials.gov) for fibromyalgia soon in the USA. I purchased it via www.antiaging-systems.com in Great Britian.
The only thing beyond the MAOI(A)+TCA+Psychostimulant+Lithium that I feel will provide relief to those with severe TRD is the deep brain stimulation device that Dr. Helen Mayberg founded showing that virtually all of those with depression suffer from an overactive (PET scans) part of the brain in the prefrontal cortex called Brodmann Area (25). Broadmann Area always returns to normal or becomes less active upon recovery from depression, but those who never or only partially recovery from depression continue to show overactivity in this specific spot. I tried to enter one of the studies being done in Dallas, but since I had several seizures while receiving trazodone and ECT (70 of them) in 1986, I was unable to participate in the study. Those wishing to learn more can visit www.BroadenStudy.com.
The other hopeful meds in the pipeline can be viewed on www.neurotransmitter.net/newdrugs/html.
Thanks,
Jeff
poster:CaptainAmerica1967
thread:868231
URL: http://www.dr-bob.org/babble/20081214/msgs/869161.html