Posted by desolationrower on December 18, 2008, at 12:26:42
In reply to Re: TRD --SLS, CPTAmerica, posted by CaptainAmerica1967 on December 18, 2008, at 4:06:01
> Thanks for your feedback.
>
> I haven't tried buprenorphine, but have been interested in it as I'm interested in almost anything that could bring about a better life. I'm not sure about the drug interaction with Parnate and would have to do some more research on it. I have a gut feeling my depression could be related to some sort of malfuncition with the hypothalamus-pituitary-adrenal axis (hot flashes or feeling warm all the time)-cortisol, endorphins, neurotransmitters. Obviously exercise affects mood as a result from many different physiological mechanisms, but it's only the intense physical exercise that produces the slight euphoria and antidepressant effect I feel which could be attributed to endorphins hence buprenorphine or naltrexone might help. Also, my father got "hooked" on heroin the first time he tried it in 1972 and died from an accidental overdose (sad to know that the following day he was suppose to go in for treatment, but never made it) so this could point to my depression as having some type of opioid dysfunction. Dextromethorphan would be interesting to try too if I weren't on an MAOI.Hm, given the relationship of opiods and your family tradegies i can see it being a complicated subject for you.
One more idea i thought of last night, stimulant-type drugs seem to help, have you ever gotten ahold of an H3 antagonist? Betahistine is the only one i think that is easily availible, its also a H1 agonist i think. Its used for some sort of ear dysfunction i think, but H3 antagonists are being tested for ADHD. Given its rather broad effects (h3 antongoism on heteroreceptors disinhibits a number of neurotransmitters) slow titration since you're on an MAOI would probably be wise although no reactions have been reported. Additionally, betahistine may be metabolised by MAO so much lower doses might be needed. -> THE METABOLISM OF BETAHISTINE IN THE RAT
L. A. STERNSON 1, A. J. TOBIA 1, G. M. WALSH 1, and A. W. STERNSON 1
ABSTRACT
The metabolism of betahistine, 2-(2-methylaminoethyl)pyridine, a bio-isostere of histamine, was studied in the rat. 2-Pyridylacetic acid, which had been previously isolated as a metabolite of betahistine from dog and rabbit urine, was isolated from rat urine as well as from rat liver homogenates. In addition, trace amounts of the N-demethylated product, 2-(2-aminoethyl)pyridine, was isolated from liver homogenates. In vitro studies revealed that the preponderance of betahistine oxidase activity originated in liver mitochondria and was attributable to monoamine oxidase (MAO). The participation of mitochondrial MAO in metabolism was corroborated by inhibiting betahistine oxidation with specific MAO inhibitors. Additional experiments ruled out the involvement of diamine oxidase in betahistine metabolism. The kinetics for the MAO-catalyzed oxidation of betahistine was studied and revealed that betahistine had a greater affinity for mitochondrial MAO (KM = 3.3 x 10-5 M) than did tyramine, serotonin, or benzylamine.Also, read this patent application for betahistine use-> http://www.wipo.int/pctdb/en/wo.jsp?wo=2007076140&IA=US2006049321&DISPLAY=DESC
Lots of stuff in there, they think it normalises HPA same as MAOIs.
Hm, someone else had the same idea, i found this now: ongoing study -> http://clinicaltrials.gov/ct2/show/NCT00585585Quite promising.
-d/r
poster:desolationrower
thread:868231
URL: http://www.dr-bob.org/babble/20081214/msgs/869439.html