Posted by desolationrower on December 16, 2008, at 21:56:34
In reply to Re: Treatment Resistant (Refractory) Depression, posted by CaptainAmerica1967 on December 16, 2008, at 20:39:02
> The only thing beyond the MAOI(A)+TCA+Psychostimulant+Lithium that I feel will provide relief to those with severe TRD is the deep brain stimulation device that Dr. Helen Mayberg founded showing that virtually all of those with depression suffer from an overactive (PET scans) part of the brain in the prefrontal cortex called Brodmann Area (25). Broadmann Area always returns to normal or becomes less active upon recovery from depression, but those who never or only partially recovery from depression continue to show overactivity in this specific spot. I tried to enter one of the studies being done in Dallas, but since I had several seizures while receiving trazodone and ECT (70 of them) in 1986, I was unable to participate in the study. Those wishing to learn more can visit www.BroadenStudy.com.
> The other hopeful meds in the pipeline can be viewed on www.neurotransmitter.net/newdrugs/html.
The new somatic treatments do look quite interesting. transcranial mag stimulation as well, even outside affective disorders, it has potential for autism, or even for inducing creative and altered states of consciousness at the touch of a button. It woudl be facinating to sit down and become extrondinarily creative or experience a different personality. There is also ultrasound treatment on the horizon that promises a more accurate targeting of brain region for stimulation. Its too bad you can't try out a new treatment.
Also, looking at your combination, only Li directly affects the glutamate system. I think that might be the area where new drugs become availible. have you tried adding something glu related, like a supplement like acetyl cysteine or aniracetam to MAOI(A)+TCA+Psychostimulant+Lithium? I really believe that for the hardest disorders, multifactorial approach is needed. Even one flat tire is a problem, even if you've got the other 3 aired up.