Posted by CaptainAmerica1967 on December 18, 2008, at 4:06:01
In reply to TRD --SLS, CPTAmerica, posted by desolationrower on December 17, 2008, at 23:01:12
Thanks for your feedback.
I haven't tried buprenorphine, but have been interested in it as I'm interested in almost anything that could bring about a better life. I'm not sure about the drug interaction with Parnate and would have to do some more research on it. I have a gut feeling my depression could be related to some sort of malfuncition with the hypothalamus-pituitary-adrenal axis (hot flashes or feeling warm all the time)-cortisol, endorphins, neurotransmitters. Obviously exercise affects mood as a result from many different physiological mechanisms, but it's only the intense physical exercise that produces the slight euphoria and antidepressant effect I feel which could be attributed to endorphins hence buprenorphine or naltrexone might help. Also, my father got "hooked" on heroin the first time he tried it in 1972 and died from an accidental overdose (sad to know that the following day he was suppose to go in for treatment, but never made it) so this could point to my depression as having some type of opioid dysfunction. Dextromethorphan would be interesting to try too if I weren't on an MAOI.
I cannot recall the dose of memantine (10mgs twice day or whatever the dose was BID). NAC is in my life extension multivitamin mix and I've used it for years.