Posted by CaptainAmerica1967 on December 17, 2008, at 10:05:57
In reply to Re: Treatment Resistant (Refractory) Depression, posted by desolationrower on December 16, 2008, at 21:56:34
Thanks for your response.
"acetyl cysteine or aniracetam"- yes I tried both of these; I've been into holistic health for years (Life Extension Foundation) and have taken acetyl cysteine before.
I've tried aniracetam and some other "smart drugs" after reading the book "Smart Drugs & Nutrients years ago by Ward Dean, M.D..I've been very interested in NMDA receptor antagonists after the news of ketamine having such a profound and lasting effect on TRD and looked into going to the NIMH in Bethesda, MD, for a ketamine study on treatment resistant depression but it would have meant having to go off the antidepressant I was taking at the time or any antidepressant for that matter for a washout time and I get severely non functional just after being off them for two days. I've tried memantine without any benefit and have thought about trying the med for ALS(Lou Gehrig's Disease) called Riluzole which is also a potent glutamate blocker or NMDA receptor antagonist (clinicaltrials.gov), but the cost is phenomenol at $10-$20 per pill and the dose of at least two per day.
I thought about trancranial magnetic stimulation (TMS), but since I failed a course of 70 ECT treatments, the TMS wouldn't likely to anything.
I'm also interested in cortisol blockers being studied.
Jeff
poster:CaptainAmerica1967
thread:868231
URL: http://www.dr-bob.org/babble/20081214/msgs/869222.html