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thanks / how it's goin' / supplementary whining » SLS

Posted by S.D. on June 4, 2000, at 22:19:31

In reply to Re: seems that modafinil *does* induce... » S.D., posted by SLS on June 2, 2000, at 18:37:19

>Hi S.D.
>
> How's it goin'?

Hi SLS, thanks for asking. I guess it's goin' pretty swimmingly. I've got antidepressants that have eventually worked for me (at least for a while, but long enough to lift me out of The Pit) and at least one med that seems to work decently for Social Anxiety. The main reasons it's not exactly cool as a moose are that
A) while I feel less anxiety when I'm "put on the spot", I haven't the 1st clue about proactively acquiring friends or breaking into particular social groups.
and
2) ...well, it's non-psycho stuff so I'll spare everyone ;^)

> So...
>
> more GABA = less dopamine
> less GABA = more dopamine
>
> more GABA = less norepinephrine (noradrenaline)
> less GABA = more norepinephrine (noradrenaline)
>
> more GABA = less excitation
> less GABA = more excitation
>
> more GABA = less anxiety
> less GABA = more anxiety
>
> Modafinil => less GABA => more anxiety
> Neurontin => more GABA => less anxiety
>
> Many of the anticonvulsant mood stabilizers increase GABAergic neurotransmission. This may be the reason why Neurontin seems to be effective for treating anxiety and social-phobia.
>
> Now, are you less excited or more excited for having read this?
>

More perplexed mainly. Not about your answer, which was great. Rather about how increasing GABA has been associated with an anti-social-anxiety effect, yet so have MAOIs which result in the opposite effect on dopamine and norepinephrine. Oh well, I don't care so much anymore 'cuz I've been spending too much time studying this stuff as it is (instead of what I'm supposed to be studying - right now in fact - which is what my problem "2" above was about, the details of which I promised to spare you).

> Sincerely,
> Scott

back atcha

peace and health,

S.D.


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poster:S.D. thread:34862
URL: http://www.dr-bob.org/babble/20000603/msgs/36045.html