Posted by SLS on June 2, 2000, at 18:37:19
In reply to Re: seems that modafinil *does* induce... » SLS, posted by S.D. on June 2, 2000, at 15:25:38
> > On the contrary, it seems that modafinil *does* induce the release of dopamine in limbic structures through the inhibition of GABAergic neurotransmission.
> >
>
> I'm kinda dense on the biochemistry stuff, but I always take note of stuff relating to GABA due to it's relevence to Social Anxiety. Does your above statement mean it inhibits GABA receptors? Why does inhibition of GABAergic neurotransmission induce the release of dopamine?
>
> Thanks
>
> peace and health,
>
> S.D.
Hi S.D.How's it goin'?
Modafinil (Provigil) does not block (antagonize) GABA receptors. It decreases the level of GABA within the synapse due to a reduction of its release. These GABAergic neurons are designed to inhibit dopaminergic neurons and pathways, along with other excitatory pathways.
So...more GABA = less dopamine
less GABA = more dopaminemore GABA = less norepinephrine (noradrenaline)
less GABA = more norepinephrine (noradrenaline)more GABA = less excitation
less GABA = more excitationmore GABA = less anxiety
less GABA = more anxietyModafinil => less GABA => more anxiety
Neurontin => more GABA => less anxietyMany of the anticonvulsant mood stabilizers increase GABAergic neurotransmission. This may be the reason why Neurontin seems to be effective for treating anxiety and social-phobia.
Now, are you less excited or more excited for having read this?
Sincerely,
Scott
poster:SLS
thread:34862
URL: http://www.dr-bob.org/babble/20000526/msgs/35757.html