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Re: Amisulpride, Amineptine....Anna

Posted by AndrewB on June 2, 2000, at 1:43:27

In reply to Re: Amisulpride, Amineptine, posted by Anna P. on June 1, 2000, at 18:34:23

Anna,

I'm so glad to see your post. I haven't heard from you in a long time and I was so worried.

You sound so down. Try to be hopeful. I know it can seem hard or not make much sense at times but, you know, when one believes that good tiding are imminent, the wind can bring miraculous gifts in the guise of a helping hand from an old friend or some other earthly guise.

Your reaction to amineptine must have been scary. You've had similar reactions to stimulants haven't you? Amineptine increases dopamine (in the synaptic cleft) but this isn’t what caused your reaction. Through dopamine, amineptine has a cascade effect on the activity of norepinephrine. It sounds like some of your receptors that respond to norepinephrine caused your side effects, specifically, your beta andrenergic receptors. Antagonism of the beta 1 andrenergic receptor can cause side effects such as heartburn, shortness of breath, dizziness, tiredness, bradycardia and heart failure.

This does not necessarily mean you can’t take stimulants. But is does mean that you have NE dysregulation that will have to be dealt with first. Tell me, have you had a similar reaction to other stimulants? If so, you should consult your doctor, or better yet a cardiologist, about appropriate beta receptor medicines to deal with your side effects.

Sorry the amisulpride didn’t help. Did you have any reaction to it at all?

AndrewB


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