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Re: Amisulpride and Selegiline

Posted by AndrewB on May 31, 2000, at 17:54:15

In reply to Re: Amisulpride and Selegiline, posted by michael on May 30, 2000, at 14:00:15


Michael,

It sounds like you are taking a reasonable approach with your drug trials. One at a time is definitely the way to go.

Tell me how did you respond to Wellbutrin before? Did it increase your energy? Did it give you side effects?

Be careful when combining Wellbutrin and Adrafinil. Both work on NE. For example if you add a full dose of Wellbutrin to an already significant dose of Adrafinil, you might find yourself over agitated and with a rapid pulse and high blood pressure when the Wellbutrin fully kicks in.

If you haven’t experienced increased arousal either with Wellbutrin alone or this combo of Wellbutrin and Adrafinil, you may not be responsive to NE meds.

You can try a higher dose of Adrafinil, but only after you’ve given your system time (2 weeks) to stabilize on Wellbutrin. Also make sure your pulse and BP is not excessive.

Adrafinil receptors shouldn’t become tolerant after a week. I don’t think NE tolerance can work that fast. Sometimes though the increased energy might last only a week if there is an underlying metabolic insufficiency.

With the amisulpride I suggest that, yes, you do another 12.5 mg. trial for a week. If all goes well then do a 25mg. trial for a week. Hopefully this dose will give you a fuller response without the sleepiness. If this goes well you can try a 37.5mg. dose.

I reviewed some literature and I think that your idea of augmenting with selegiline is worth a try. You may experience increased energy and mood at a dose of 5 to 15 mg. I forget how long the effect takes to kick in. Again, don’t do this trial until you have stopped fiddling with the other meds.

Phenylalanine sometimes can be added onto selegiline with good results. I would give it a try. The trial need only take four days and it is available at the health food store.

St. John’s Wort also has some dopamine inhibition. I like what it has done for me. It seems to be gently uplifting of energy and mood.

Please let me know how it goes with your amisulpride trials and your selegiline augmentation.

Do you have a couple of favorite international pharmacies that you haven't already told me about. If so, drop me a line. I'm going to put together a list. Of course, non prescript. sources are of the most interest.

Best wishes,

AndrewB


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