Posted by SLS on June 2, 2000, at 9:50:58
In reply to Re: Amisulpride, Amineptine....Anna, posted by JohnL on June 2, 2000, at 3:24:57
> Anna,
>
> I'm very sorry about Amineptine. That must have been a scary frustration. I hope you're feeling a little better now.
>
> I was reading in the Physician's Desk Reference about the narcolepsy stimulant Provigil (Modafinil). Have you tried this one yet? The reason I ask is because it is described as having dopamine reuptake action without increasing the output of dopamine. Though it has other modes of action which may or may not be good for you--don't know--I thought the part about dopamine reuptake inhibition was worth noting.
> JohnL
I really like JohnL's suggestion.Andrew made a good comment regarding Chronic Fatigue Syndrome. Has anyone ever suggested to you that you might have Mitral Valve Prolapse?
John - Someone told me about the Provigil package insert describing that it exerted some dopaminergic activity. I have not seen this cited on Medline. The studies I have seen concluded quite emphatically that it does not affect dopamine reuptake at the synapse. What's the deal? Would you be kind enough to summarize its pharmacology to me. If it is dopaminergic, I would really like to know this before my next doctor's visit on Wednesday. Does adrafinil do the same thing? If I were a cynic, I would say that the drug company is full of crap and just wants to cover all bases for treating narcolepsy.
Does the PDR give a bibliography?
On the contrary, it seems that modafinil *does* induce the release of dopamine in limbic structures through the inhibition of GABAergic neurotransmission.
Amineptine:Along with its ability to inhibit the reuptake of dopamine (DA), amineptine also inhibits the reuptake of (NE). This is probably the more likely explanation for such an acute autonomic response.
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For Anna and other person =>
Who wrote the following? I'm sorry I never saw it."> I responded to Amineptine when in a severe episode of my seasonal depression, but not to the amisulpride.
I can't tolerate any more stimulating drugs, although I need them. What's wrong with me?
SLS - what is the problem with the autonomic system?"What is your diagnosis?
Can you list the drugs or drug combinations you have tried?
Which gave you some improvement? How long did it take to feel the improvement? How long did last? What were the side effects?
Which stimulants have you tried? What were the side effects?
Without medication-induced side effects, which of these do you experience:
- dry mouth
- constipation
- heart palpitations
- sweating
- dizziness when you stand up
- unexplained changes in heart rate
- sudden breathlessness
- TMJ
- fibromyalgia
- tinnitus (ringing or buzzing in the ears)
- indigestion
- irritable bowel
- chronic fatigue/weakness
- panic attacks
Is there any history of cardiac disease/arrhythmia in your family? Irritable bowel? Mitral-Valve Prolapse? Diabetes? Anything?
Have you ever tried either a tricyclic or MAO inhibitor?
- Scott
poster:SLS
thread:34862
URL: http://www.dr-bob.org/babble/20000526/msgs/35652.html