Posted by raybakes on November 1, 2004, at 7:38:03
In reply to Re: Bowel toxins,enzyme peptide conversion of aminos? » raybakes, posted by Larry Hoover on October 31, 2004, at 9:02:53
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> A sulphotransferase is the enzyme which conjugates, via sulphonation, some substrate. That targets it for excretion, while at the same time, blocking its metabolic activity.
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> The corollary deconjugating enzyme is a sulphonase.Hi Lar, the articles I've been reading call the deconjugating enzyme sulfatase/sulphatase?
Found this abstract interesting - infection/inflammation can decrease the availability of sulphate but upto 80%
Autism And Sulphation: The Role Of Cytokines
As sulphate is required for the synthesis of gut mucins and the functioning of the digestive system, infections or inflammatory responses would depress the body’s capacity to break proteins down to amino-acids, resulting in higher levels of peptides, and would also lead to ‘leaky gut ‘syndrome.
http://www.mindofachildaustralia.org/abstract-waring.html
> >
> I just want to say that most of the drug interactions that people get concerned about actually take place in the wall of the intestine....at least those which have immediate
effect.if the drugs are reacting with dextoxification enzymes in the gut, doesn't this have implications for the whole body, and the brain?
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> My central point, hitherto unexpressed, is that there is a lot more to "hepatic" enzymes than meets the eye. We're only just starting to understand the complexity of interactions. Rather than trying to affect a specific aspect of e.g. hepatic function, it makes more sense to promote hepatic health. Unless, of course, a specific disorder is being considered.
I still feel that a toxic bowel will overload detoxification enzymes in the bowel and put more of a load on detoxification elsewhere in the body - including the brain. Do you not feel that is possible?Thanks for the debate/chat/information - hope it's not getting too heavy!
Ray
poster:raybakes
thread:407758
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/409949.html