Posted by raybakes on November 1, 2004, at 7:51:15
In reply to Re: Bowel toxins,enzyme peptide conversion of aminos? » raybakes, posted by Larry Hoover on October 31, 2004, at 8:41:43
Hi Lar, I wasn't trying to be specific about this enzyme, just as part of the picture of how bowel imbalance can impact the whole body - i realise nothing is usually good or bad, just out of balance.
> > Possibly, but the total circulating estrogen concentration is dependent, via feedback regulation, on the integrated estrogen level itself. Real-time estrogen concentration sampling regulates estrogen production; it is not relevant whether the sampled estrogen is de novo or recycled. If "unnatural" estrogen is an issue, what about the profound influence of exogenous estrogen from birth control or hormone replacement therapy?
But we do have an epidemic of estrogen sensitive cancers - if the feedback worked well surely these cancers wouldn't be occuring? It wasn't really the beta glucuronidase I wanted to focus on, it was again the balance of the bowel and it's implications on the health of the rest of the body.....
Estrogens, breast cancer, and intestinal flora.
Gorbach SL.
Epidemiologic evidence has linked diet to breast cancer, with the highest cancer rates observed in women who eat a high fat-low fiber diet. There is also substantial information, both clinical and experimental, that implicates estrogens in the etiology of breast cancer. A recent study from our laboratory has shown that diet influences levels of estrogens, and the main mechanism is metabolism of estrogens in the intestine. The intestinal microflora plays a key role in the enterohepatic circulation of estrogens by deconjugating bound estrogens that appear in the bile, thereby permitting the free hormones to be reabsorbed. By suppressing the microflora with antibiotic therapy, fecal estrogens increase and urinary estrogens decrease, changes indicating diminished intestinal reabsorption. A low fat-high fiber diet is associated with similar findings-high fecal estrogens and low urinary estrogens. It appears that the microflora plays a key role in the metabolism of female sex hormones.
Ray
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poster:raybakes
thread:407758
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/409954.html