Posted by raybakes on October 31, 2004, at 7:33:52
In reply to Re: Bowel toxins,enzyme peptide conversion of aminos? » raybakes, posted by Larry Hoover on October 30, 2004, at 8:12:00
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> There are multiple excretory routes into the gut, and thus into feces. One is via bile, the direct excretion from liver to gallbladder to feces. That there are organisms within digestive tracts which can utilize conjugated compounds is of no surprise to me. However, the contents of the gut are outside the body. The issue for me is not that it might happen, but what is the yield? I doubt the proportion of excreted conjugates which are deconjugated and made available for reuptake is large. And even if it is so, the liver and mesenteric enzymes still get another crack at them, via the portal circulation.
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Hi Lar, it was the link with breast cancer and beta glucuronidase that got me thinking about recirculation of deconjugated toxins. In alternative medicine review, it claims the build up of glucuronidase in the gut allows estrogens to recirculate and increase cancer risk in estrogen sensitive tissue - so I think recirculation of toxins is a factor in the effects of bowel flora imbalances.Calcium-D-glucarate.
Calcium-D-glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by mammals, including humans. Glucaric acid is also found in many fruits and vegetables with the highest concentrations to be found in oranges, apples, grapefruit, and cruciferous vegetables. Oral supplementation of calcium-D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microflora and involved in Phase II liver detoxification. Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers. Other potential clinical applications of oral calcium-D-glucarate include regulation of estrogen metabolism and as a lipid-lowering agent
ray
poster:raybakes
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URL: http://www.dr-bob.org/babble/alter/20041022/msgs/409479.html