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Re: Memantine as a reversible MAO Inhibitor?

Posted by g_g_g_unit on October 16, 2009, at 20:00:47

In reply to Re: Memantine as a reversible MAO Inhibitor?, posted by Rosy Crucifiction on October 16, 2009, at 11:22:02

> Memantine is clearly a weird drug. If I read the paper correctly, the authors say that taking 20 mg a day eventually leads to plasma concentrations high enough to lead to brain levels where MAO inhibition occurs. So it could be that negative reports have to do with a period where NMDA blockage led to uncomfortable side effects but MAO inhibition hadn't (yet?) occurred. So maybe it would have worked over a longer period of time.
> How long where you at 20 mg? looking back do you think it could be too low a dose, too high a dose (you said you did well on 5mg) or ot long enough at 20mg. I'd appreciate a gut check, since I suspect I'm about to deal with the same sort of thing.

i was only on 20mg for about two weeks. the effect was really inconsistent; there were days at 10/15mg where i felt incredibly placated and at peace, then others where i felt kinda down. 5mg was the best for social anxiety, but worsened my compulsions. i was just following the guideline which recommends 20mg .. i mean, i read about another girl who took 5mg twice a day to clear up brain fog while on mood stabilizers and that worked perfectly for her; she'd been on it for a year. it has some action on acetylcholine downregulation which i had read only lasts a week (hence the initial fuzziness) which is why i wasn't especially patient; but maybe the MAO effect warrants more time like you say.

unfortunately, like i mentioned the drug's a little too expensive to experiment with it. i might buy the generic online and try adding it to parnate or whatever i try next.

 

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