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Related: mematine methylphenidate synergy?

Posted by Rosy Crucifiction on October 18, 2009, at 13:20:43

In reply to Re: Memantine as a reversible MAO Inhibitor?, posted by Rosy Crucifiction on October 18, 2009, at 13:06:33

I added memantine to my concerta at onset hoping to ward off the tolerance I'd previously experienced with methylphenidate. The concerta form is new to me and has a very different effect form Ritilan. Long slow ramp to stimulation, so no euphoria or drug seeking. But it has eradicated my paralyzing fatigue.
More of a surprise to me is the combined effect on anhedoia. Doing a little reading, I found one study showing the tolerance preventing effect of mem. on methyl. in mice. Another showing memantine increases dopamine release in rat prefrontal cortex and striatum. Particularly D2, which seems to be related to the pleasure derived from drinking alcohol. And I've been drinking less. It's nice when there's a period of relief.

see: NMDA receptor antagonist disrupts acute and chronic effects of methylphenidate.
Yang P, Swann A, Dafny N.

Memantine-induced dopamine release in the prefrontal cortex and striatum of the rat--a pharmacokinetic microdialysis study.
Spanagel R, Eilbacher B, Wilke R.

http://www.ionchannels.org/showabstract.php?pmid=18000814&redirect=yes&terms=d2+dopamine+memantine

Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors
Tamara J. Phillips1, 2, 3, Kelly J. Brown3, Sue Burkhart-Kasch2, 3, Charlotte D. Wenger1, 2, 3, Michele A. Kelly4, 5, Marcelo Rubinstein7, David K. Grandy2, 5, 6 & Malcolm J. Low2, 4


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poster:Rosy Crucifiction thread:921016
URL: http://www.dr-bob.org/babble/20091012/msgs/921406.html