Posted by Rosy Crucifiction on October 16, 2009, at 11:22:02
In reply to Re: Memantine as a reversible MAO Inhibitor?, posted by g_g_g_unit on October 16, 2009, at 5:51:00
Memantine is clearly a weird drug. If I read the paper correctly, the authors say that taking 20 mg a day eventually leads to plasma concentrations high enough to lead to brain levels where MAO inhibition occurs. So it could be that negative reports have to do with a period where NMDA blockage led to uncomfortable side effects but MAO inhibition hadn't (yet?) occurred. So maybe it would have worked over a longer period of time.
How long where you at 20 mg? looking back do you think it could be too low a dose, too high a dose (you said you did well on 5mg) or ot long enough at 20mg. I'd appreciate a gut check, since I suspect I'm about to deal with the same sort of thing.