Posted by g_g_g_unit on October 16, 2009, at 5:51:00
In reply to Re: Memantine as a reversible MAO Inhibitor?, posted by Rosy Crucifiction on October 15, 2009, at 23:22:02
> Yes. I'm currently taking:
> memantine 15 mg. (start 20 next week)
> wellbutrin xl 300 mg (brand - generic sucks)
> concerta 72 mg (MUCH better than ritilin for me)
> liorix 150 mg (150 mg t4 / 30 mg t3)
> test. cypionate
> I am MDD no psychosis, ADHD (inattentive), SAD and soft bipolar 2. The memantine has added real antidepressant effect and some hints of ability to experience pleasure. Titration has been tough for me. The first 3-4 days at 5 mg and at each 5 mg increase I have felt weak, strange, and like I couldn't handle the med. Within 4-5 days taht has changed to a real brightening of mood and a feeling of hopefulness. I now feel well enough to sign up for outpatient treatment at a depression center hospital (it's tough when you're too sick to deal with getting better). Anyway, the MAO bit is quite interesting. The NMDA agonist Riluzole is supposed to be better for depression, but is about $600 a month. And nothing I can find about MAOI effetcs. I am curious if anyone out there knows anything about memantine and MAO.
i tried memantine as monotherapy. at 5mg it had a pleasant stimulating effect; the higher i went up the more anxiolytic it became, but i got really bad brain fog on it. the highest i went was 20mg.
i couldn't afford to take a really high dose (40mg a day or whatever) since i was taking the brand name, and medical insurance doesn't cover meds (especially off-label Alzheimers drugs) where i live.
anyway, once i began to taper off, there were a couple of days where i felt really good. i wonder if due to the long half-life i was taking too much for my individual case. i also wondered if maybe since the drug stabilizes the glutamate system, it might work better with another drug that's stimulating glutamate in some way. otherwise you just end up with the kind of middling depersonalization i experienced. that's my layman's theory anyway. i considered trying it with Wellbutrin at some point.