Posted by Medline on January 27, 2009, at 18:35:51
In reply to Re: I'm 100% cured of Social Phobia!!! » Medline, posted by Vincent_QC on January 27, 2009, at 6:18:38
> The 2 x 300mg Moclobemide / day = not a good AD to treat social anxiety...I have a lot of skepticism about it...that's not for nothing if it's not approved in the States...
The RIMA Moclobemide is not as effectiv as MAOIs, but it's easier to handle and safer as no diet restrictions have to be followed. Could you explain your sceptimism? Do you think it is dangerous? MAOIs are approved and altough pretty safe, they are more dangerous than Moclobemide.
http://www.ncbi.nlm.nih.gov/pubmed/12131599
http://www.ncbi.nlm.nih.gov/pubmed/9177952
http://www.ncbi.nlm.nih.gov/pubmed/1393304> The 2mg Selegiline / day = Ok...I mean if you need to have some energy.
I need the Dopamine! By combining Moclobemide with low dose Selegiline I don't have to follow diet restrictions and have a robust antidepressive effect. Not as strong as with classical MAOIs probably, but definitely stronger than with Moclobemide alone.> The 4 x 1.5ml of GBL / day = Not legal in my country...the 2 chimical products to make it are legal...but for me it's just a cheap street drug...and dangerous also...In fact, I try the GHB one time as a street drug...no comment...Benzo drugs are more powerfull than this, you have to mix it with alcohol to feel something...I'm not sure about the tolerance also...look like it will poop-out one of these day and stop working...
You know everything about GHB because you used it once (at least what you thought was GHB). You bought it illegaly on the street and took it not knowing what dose it is? Then you recommend combining Benzos with the "cheap street drug" alcohol. Very responsible, thank you for the tip!
> 50mg Baclofen / night = A muscle relaxant who act as a GABA antagonist ... Hummm a lot of skepticism about this one also. I don't know why so many people point the gaba-B as a good choice or a good target to reduce anxiety, I never get improve on my social phobia from Lyrica or Gabapentin or any others gaba-b drugs... Tolerance also occur after a while with them...
It's a GABA agonist, not an antagonist (which is the complete opposite). Pregabalin (Lyrica) and Gabapentin (Neurontin) are NOT GABAergic drugs. Baclofen has anxiolytic proberties and helps me not using GBL at night.
>The 50mg Cycloserine / day = An antibiotic ...The human body get used fast of them, you can'T stay on a antibiotic for the rest of your life...
For tuberculosis 10x-20x higher doses are used than for fear extinction. It doesn't act as an antibiotic at just 50mg. And it's not to be taken forever.
> 2mg Klonopin on the weekend...hummm very addictive for someone who have social phobia...and tolerance occur often also...and 2 days of holidays between the Baclofen + GBL is not a lot, I mean, to prevent addiction from the Baclofen and the GBL it's too short...the half-life of these products are probably more long than 48 hours...
First you recommend Benzos then you wish them to hell. Benzodiazepine tolerance and dependence does not occur when someone just takes it on weekends. 48 hours+ is the completely wrong answer by the way. Baclofen has a mean half-life of 3.5 hours. GBL has a half-life of 3-5 minutes and it's about 30-40 minutes for it's metabolite GHB which is undetectable in blood or plasma after about 6-8 hours.
> I think mixing too much drugs like this will make you feel worse with time. The best solution is often the simple ones...Also, try to find a Psychiatrist who will help you to be on this cocktail in the States or the Canada...good luck, especially for the GBL...
I don't live in Canada ;-). I think the dose makes the poison and for many drugs I use very low doses. For spasticity up to 300mg of oral Baclofen are prescibed, my maximum is 50. Selegiline is used in doses up to 20-30mg and for therapy-resistant depressives 60mg have been tried, I take 2mg! Cycloserine I take 1/20-1/10 of the usual anti-tuberculosis dose and 4mg Klonopin / week is not much too.> Like I already write before, social anxiety can't be cured...but you can find some relief of it with the use of some drugs...but the main part is to learn how to cope with that disease with a good CBT...a lot of exposure time in social events and things like that...Depression can get cured or at least control, co-morbidities who became more and more dominant after a while can be cured (Depression. general anxiety, panic disorder)...but not social phobia...I mean, you can learn to control it but not cured it at 100%...One of these day, something will stop working in your mix...Rivotril, GBL, Baclofen...all potential addictive drugs...The only more stable drugs who will not cause addiction on your list seem to be the Manerix and the Selegiline.
We will see if they stop working. :-). Maybe the Cycloserine has made the results permanent until then.
> That's what I think. I prefer to have a "partial" answer on one drug at the time like the Nardil, the Parnate or the Marplan...The theory of the elevating levels of 5-HT, DA, GABA, NE and Oxytocin in the CNS increases the probability of making a complete recovery is a so so point of view... I think it's different for everyone also. A lot or research point a lot to the fact that social phobia or others disease like these are genetic...and a lot of people react very well at the first line treatment drugs...other like me don't... the 5-Ht in my case make me worse (weight gain, lack of energy and motivation...), the DA sometimes make me feel more anxious and tend to make me tired, the Gaba-A or B is now an invalid option (benzo drugs don't work on me now and I never react well to gaba-B drugs...just pins and needles sensations from them), NE make my heart race (high blood pressure) and Cycloserine is it suppose to help to augment the Oxytocin level( a hypothalamic hormone) and help for social phobia??? That's really weird...
What has the partial NMDA-agonist Cycloserine to do with Oxytocin?!? GABA-B drugs you never tried, Pregabalin and Gabapentin are not GABAergic as I already wrote. Moclobemide is not known to cause Tachycardia when used in normal doses. It's more drugs that inhibit NE reuptake like Reboxetine. Future antidepressants will be triple reuptake inhibitors elevating the levels of 5-HT, NE, DA which is problably a better strategy than just raising the level of one of them.
> Anyway...good luck with your cocktail...I just can't imagine living with soo much drugs in my body...
Dose makes the poison. ;-) Selegiline for example increases lifespan of several animal species by inducing potent antioxidant enzymes.
Take care of you too, have a nice birthday!
poster:Medline
thread:876329
URL: http://www.dr-bob.org/babble/20090104/msgs/876624.html