Posted by JadeKelly on January 27, 2009, at 8:53:27
In reply to Re: I'm 100% cured of Social Phobia!!! » Medline, posted by Vincent_QC on January 27, 2009, at 6:18:38
> > First of all: Don't try this at home kids! I have year long experience with psychoactive drugs, which I am not really proud of. :-( I've made a lot of mistakes, some of which I could have paid the ultimate price for - my life. Nevertheless giving up wasn't an option for me at any point.
> >
> > SAD involves dysfunction of the Serotonin-, Dopamine-, GABA-, Oxytocin- and probably Norepinephrine-System.
> >
> > Fact: about 30-40% of patients do not adequately respond to a treatment with first line agents (SSRIs/SNRIs). These people might be helped by long term Pregabalin/Clonazepam or MAOI-treatment. But some have to be considered "therapy resistent".
> >
> > Hypothesis: Elevating levels of 5-HT, DA, GABA, NE and Oxytocin in the CNS increases the probability of making a complete recovery. Low dose of the NMDA-antagonist Cycloserine may help to "hardwire" the results in the brain.
> >
> > My regimen:
> >
> > 2 x 300mg Moclobemide / day:
> >
> > Increases levels of Serotonin and Norepinephrine.
> >
> > 2mg Selegiline / day:
> >
> > Works on Dopamine, but leaves enough Monoamine Oxidase so that Tyramine can be broken down and no special diet has to be followed.
> >
> > 4 x 1.5ml of GBL / day:
> >
> > Non-toxic precursor for GHB, legal in my country (but not in the US!). Increases levels of Oxytocin, GHB and probably GABA-B in the CNS. Potent anxiolytic and empathogen.
> >
> > 50mg Baclofen / night:
> >
> > Extremely important! Never take GHB/GBL 24/7 or severe dependence and withdrawal will occur. Baclofen helps with that and you can sleep very well and resftul.
> >
> > 50mg Cycloserine / day:
> >
> > May help to make the results permanent.
> >
> > I take this from Monday-Friday. On weekends I take 2mg Klonopin / day instead of Baclofen and GBL to avoid tolerance and physical dependence.
> >
> > This cocktail completely kills SA and depression. I've tried all Psychodrugs known to man (SSRIs/SNRIs, tricyclic and atypical ADs, MAOIs, Mood stabilizers, Neuroleptics, Alcohol, Benzos, Phenobarbital, Clomethiazole, Buprenorphine) but nothing works as effectively as this regimen.
> >
> > What do you think?
>
> Don't want to be negative, but for me, it's look like a shopping list...
>
> The 2 x 300mg Moclobemide / day = not a good AD to treat social anxiety...I have a lot of skepticism about it...that's not for nothing if it's not approved in the States...
>
> The 2mg Selegiline / day = Ok...I mean if you need to have some energy.
>
> The 4 x 1.5ml of GBL / day = Not legal in my country...the 2 chimical products to make it are legal...but for me it's just a cheap street drug...and dangerous also...In fact, I try the GHB one time as a street drug...no comment...Benzo drugs are more powerfull than this, you have to mix it with alcohol to feel something...I'm not sure about the tolerance also...look like it will poop-out one of these day and stop working...
>
> 50mg Baclofen / night = A muscle relaxant who act as a GABA antagonist ... Hummm a lot of skepticism about this one also. I don't know why so many people point the gaba-B as a good choice or a good target to reduce anxiety, I never get improve on my social phobia from Lyrica or Gabapentin or any others gaba-b drugs... Tolerance also occur after a while with them...
>
> The 50mg Cycloserine / day = An antibiotic ...The human body get used fast of them, you can'T stay on a antibiotic for the rest of your life...
>
> 2mg Klonopin on the weekend...hummm very addictive for someone who have social phobia...and tolerance occur often also...and 2 days of holidays between the Baclofen + GBL is not a lot, I mean, to prevent addiction from the Baclofen and the GBL it's too short...the half-life of these products are probably more long than 48 hours...
>
> I think mixing too much drugs like this will make you feel worse with time. The best solution is often the simple ones...Also, try to find a Psychiatrist who will help you to be on this cocktail in the States or the Canada...good luck, especially for the GBL...
>
> Like I already write before, social anxiety can't be cured...but you can find some relief of it with the use of some drugs...but the main part is to learn how to cope with that disease with a good CBT...a lot of exposure time in social events and things like that...Depression can get cured or at least control, co-morbidities who became more and more dominant after a while can be cured (Depression. general anxiety, panic disorder)...but not social phobia...I mean, you can learn to control it but not cured it at 100%...One of these day, something will stop working in your mix...Rivotril, GBL, Baclofen...all potential addictive drugs...The only more stable drugs who will not cause addiction on your list seem to be the Manerix and the Selegiline.
>
> That's what I think. I prefer to have a "partial" answer on one drug at the time like the Nardil, the Parnate or the Marplan...The theory of the elevating levels of 5-HT, DA, GABA, NE and Oxytocin in the CNS increases the probability of making a complete recovery is a so so point of view... I think it's different for everyone also. A lot or research point a lot to the fact that social phobia or others disease like these are genetic...and a lot of people react very well at the first line treatment drugs...other like me don't... the 5-Ht in my case make me worse (weight gain, lack of energy and motivation...), the DA sometimes make me feel more anxious and tend to make me tired, the Gaba-A or B is now an invalid option (benzo drugs don't work on me now and I never react well to gaba-B drugs...just pins and needles sensations from them), NE make my heart race (high blood pressure) and Cycloserine is it suppose to help to augment the Oxytocin level( a hypothalamic hormone) and help for social phobia??? That's really weird...
>
> Anyway...good luck with your cocktail...I just can't imagine living with soo much drugs in my body...
>
> I guest you know what you are doing...and I really hope you will stay cured of the social phobia!!! ;-)
>
> Don't take it badly...I mean maybe it's the GOOD solution for you...All I want is to try to understand everything behind your drugs cocktail...I'm sure some drugs are not a lot usefull and others can be replace with others ones also...so muck possibilities exist now on the market...and the fact that we all react differently on a drug, make your cocktail less suitable for the others...
>
> Well, take care of you ok!!!
>
> Bye!
>
> Vincent ;-)
Hi Vincent!Thank you for posting that. It sounds like its a BIG cocktail working for one person for now, but it concerns me that others would "try this at home" with the possibly of a very unfavorable outcome.
~Jade
PS-Hope it keeps working for you Medline!
poster:JadeKelly
thread:876329
URL: http://www.dr-bob.org/babble/20090104/msgs/876519.html