Posted by Medline on January 26, 2009, at 13:16:18
First of all: Don't try this at home kids! I have year long experience with psychoactive drugs, which I am not really proud of. :-( I've made a lot of mistakes, some of which I could have paid the ultimate price for - my life. Nevertheless giving up wasn't an option for me at any point.
SAD involves dysfunction of the Serotonin-, Dopamine-, GABA-, Oxytocin- and probably Norepinephrine-System.
Fact: about 30-40% of patients do not adequately respond to a treatment with first line agents (SSRIs/SNRIs). These people might be helped by long term Pregabalin/Clonazepam or MAOI-treatment. But some have to be considered "therapy resistent".
Hypothesis: Elevating levels of 5-HT, DA, GABA, NE and Oxytocin in the CNS increases the probability of making a complete recovery. Low dose of the NMDA-antagonist Cycloserine may help to "hardwire" the results in the brain.
My regimen:
2 x 300mg Moclobemide / day:
Increases levels of Serotonin and Norepinephrine.
2mg Selegiline / day:
Works on Dopamine, but leaves enough Monoamine Oxidase so that Tyramine can be broken down and no special diet has to be followed.
4 x 1.5ml of GBL / day:
Non-toxic precursor for GHB, legal in my country (but not in the US!). Increases levels of Oxytocin, GHB and probably GABA-B in the CNS. Potent anxiolytic and empathogen.
50mg Baclofen / night:
Extremely important! Never take GHB/GBL 24/7 or severe dependence and withdrawal will occur. Baclofen helps with that and you can sleep very well and resftul.
50mg Cycloserine / day:
May help to make the results permanent.
I take this from Monday-Friday. On weekends I take 2mg Klonopin / day instead of Baclofen and GBL to avoid tolerance and physical dependence.
This cocktail completely kills SA and depression. I've tried all Psychodrugs known to man (SSRIs/SNRIs, tricyclic and atypical ADs, MAOIs, Mood stabilizers, Neuroleptics, Alcohol, Benzos, Phenobarbital, Clomethiazole, Buprenorphine) but nothing works as effectively as this regimen.
What do you think?
poster:Medline
thread:876329
URL: http://www.dr-bob.org/babble/20090104/msgs/876329.html