Posted by Vincent_QC on January 31, 2009, at 12:51:30
In reply to Re: -d/r (One question), posted by medline on January 31, 2009, at 11:54:33
> Great that your sober! Regarding the Selegiline: This combination is contraindicated, I think the risk of a hypertensive crisis is elevated. I wouldn't take Phenelzine + Selegiline. If you want a more energizing agent you could try Parnate. You could also slowly and carefully add Modafinil to the Nardil.
>
> I know that Tiagabine (Gabatril) is a GABA reuptake inhibitor, sometimes used off-label for anxiety. As a metabolite of Phenelzine is a potent GABA transaminase inhibitor (increases brain GABA levels) it could act synergistically with Tiagabine (and the Klonopin/Rivotril). But if you want more energy this could be counterproductive. I think Picamilon (GABA bond to Niacin) or Phenibut (pretty much like Baclofen, but some GABA-A agonism too) could help you without sedating. I have to ask again ;-) - have you tried Parnate?
>
> Have you thought about slowly tappering the Klonopin?
>
> Have a great day, Medline
Actually, i'm only on 20mg/day of Valium...I succeed to withdraw my Rivotril dosage from 8mg to 2 mg and I asked in the summer of 2007 to switch to the Valium, since it have a more half-life in the blood...so no need to pop-up a pill every 4 hours...like I do on the Rivotril before...So when I switched from the Rovitril 2mg to Valium, I used the Ashtonn Book conversion table...so 2mg Rivotril was the same as 40mg of Valium... At 40mg of Valium I had strong sedation at first but it fade away after 2 weeks...The valium never work well for social anxiety...but well the Rivotril at the end was not helpfull also...The main goal was to withdraw all the benzo drugs I taken at the time...So after 2 years i'm at 20mg of Valium, I use it just in case...it's like a prevention pills...I don't feel any effect from it, but if I don't take it, I feel a strange sensation in my head, like someone push my brain with his two hands...I fear a lot the seizure that often occurs when someone stop cold turkey the benzo drugs...
Someday, I use only 10mg, sometimes it's 20mg...since 3 weeks (i'm off any AD's...)...I use more than 20mg....up to 30mg...but all of this occur naturally...I never think about taking my pills...I just take them because i'm used off...
In 4 years of use of the benzo drugs, I was 3 weeks free in the summer of 2007...I had a major panic attack when I Was driving the car, I had some pills in my pocket so I pop-up one and I start them again...anyway...benzo drugs FOR ME, is the worst drug in the world...very effective at fisrt but also very addictive...probably related to my past addiction with drugs when I was a teenager and also the alcohol problem...Some people never developp tolerance on them BTW...
Now for the Parnate...I had a strong reaction on it...I do 1 month at 30-40mg/day...last december and begining of january 2009...I had to stop because I begin to do high blood pressure without any food interraction...spontaneous hypertensives crisis like they call them...I had to use 6 times the emergency pills (Apo-Nifed : Nifepidine) to reduce my blood pressure (220/90-100)...
I stop it 3 weeks ago...because I had to much physical fatigue...and heart problems on it...and since then, my blood pressure never return to the normal rate I had before (110/60)...
I was on the Nardil for 3 months, 75mg and 2 weeks at 90mg...in the begining of 2007...I never had a strong relief of my social anxiety on it...but it's when I succeed to reduce my rivotril dosage...I Was using them less often...I didn't notice it at the time, but now I know that it was probably a good effect on my social anxiety...
I had the same kind of reaction on the Parnate also, I was able to reduce my Valium intake on it...In fact, I was forgetted to take them... and on the Parnate, I din't feel the strange sensation in my head when I forget to take my Valium pills...so in a way, it was effective on my social anxiety i'm sure...too bad I Was not able to tolerate the high blood pressure it give to me...
Since then, my PDoc put me on the Manerix (RIMA), I do only 3 days on it, I had a terrible increasement of my anxiety...social or general anxiety and a strong migraine that never fade away...So I just stop...
The next step is to try the Marplan...It's not avaible in my Country (Canada), so me and my PDoc wanted to import it in the Canada...I found some informations on the whole process...I see my PDoc next week and we will talk about it...My PDoc talk also about the Emsam patch...but they are expensive and he is not sure where he can obtain them also...
So for now, I think I will ask to return on the Nardil...anyway the time to import and recieve the Marplan pills will be probably long...so we will see...maybe my second try on the Nardil will be better, since I take less benzo drugs...and my life for now is reduce to sleep at daytime, try to move my *ss a little bit at night and go to see the only friend I have...just to go out of my house...I don'T work and I stop the university...When I try the Nardil in 2007, I was living in another big city, I had no friends there, I had courses at the university, big works and oral presentations to do, and I was addicted to the Rivotril...now that's completly different...
On the Nardil, I also had a lot of hypotension orthostatic...it's why I stop the Nardil in 2007, I was afraid of this...and not used to this side-effects... On the Parnate, the hypotension orthostatic appear at 20mg/day...and I had severals episodes of low blood pressure also...and now I know it's not dangerous and I know also that some "Florinef" pills can make the hypotension orthostatic less harder...In fact, I think that if I had waited another 2 weeks on my first try of the nardil, probably this side-effects will had disepear...but I Was not aware about the fact that it was frequent as a side-effect, so I just freaking out and stop it...
The main problem with the Parnate was the high blood pressure...it's maybe related to his strong NE activity... and it's similarity in his structure of stimulants drugs... I think the Emsam patch hit more the MAO-B...so probably more the DA... so I Really don't know who I will react...The MAnerix was more acting on the MAO-A...and the Narcil seem to be more hard on the SE with the gaba-energic effect...
So i'm confuse a little bit...Like my PDoc told me, I seem to answer well for my social phobia to the MAOI's drugs, but he don'T know why the Nardil for example, never give me high blood pressure...and why I Was not able to tolerate the Parnate...For the Manerix, It's seem that i'm the only one who encounter the increasement of anxiety and migraine when I use it...normally, people don'T have side-effect on it , they don'T feel anything from it in fact...so that'S really strange...
I'm not an expert, but i'm sure combining the Nardil with something to help me for my energy level at daytime, without worsing my anxiety level will be very helpfull...
For the Modafinil, it's not cover by the public insurrance here...and it's very expensive...so i'm not sure...I ask for small dose of Adderall-XR before I try the Parnate and my PDoc refuse...telling me that it will increase my anxiety level...but the other PDoc I had before him give to me some Ritalin in addition to the Cipralex I was taking at the time without any problems...but the Ritalin fail to give me some energy, even at 15mg or 20mg...I only have strange sensations like hot ears (red and really hot) and more focus on what happen around me...but no more energy..
Well that'S it...another time, I write to many things...and I probably contradict myself 100 times again...lol I'm so confuse since a little while, I feel like I live in a dream...I try so many pills and combo and cocktail of drugs that I think i'm really not sure witch ones make a good effec on me or not...One thing is sure, i'm not answering to any newer drugs like the SSRI'S or the SRNI's...and to anticonvulsives drugs like GAbapentin or Lyrica...
The only things I never try are the mood stabilizer like Lithium or Lamictal...
And you're right, I don'T need something to make me feel more tired at day time so maybe the Gabatril option was not a very good idea from myself... I already have some benzo in my drugs regiment, I don'T need other drugs who will make me tired at daytime...
One thing is sure also, my new PDoc will never allow me to have a stimulant with a MAOI...it's why I ask about the Selegiline oral alone or in a combo at low dose for the Nardil...
Anyway, I will be fix more on the avaible options I have left in front of me next tuesday afternoon...and I will keep people update here...
Thanks for your advise mister!!!
Take care of you!
Vincent ;-)
poster:Vincent_QC
thread:876329
URL: http://www.dr-bob.org/babble/20090104/msgs/877367.html