Posted by SLS on December 23, 2008, at 9:38:23
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » Marty, posted by SLS on December 23, 2008, at 7:16:15
> Interesting:
> http://www.nature.com/npp/journal/v28/n2/full/1300057a.html
> To produce a treatment - whether monotherapy or polypharmacy - that will inhibit the reuptake of 5-HT and simultaneously antagonize 5-HT2a and 5-HT2c receptors in the absence of DA antagonism might be ideal to treat depression.Oops.
I managed to overlook the role that 5-HT2c receptors are suggested to play. The authors conclude that 5-HT2c agonism, and not antagonism, can act as a synergist to SRIs.
Geodon is an interesting drug. I didn't think much of it as an antidepressant augmenter when it first appeared. However, I have come to believe that it possesses an array of properties, including selective 5-HT2a receptor antagonism, that serves to explain its antidepressant properties. It really is the most antidepressant-like of the neuroleptic antipsychotics. I've seen it work wonders in TRD when added to a combination of Lexapro and Wellbutrin.
Antidepressant properties of Geodon:
5-HT1a agonist ++
5-HT1d antagonist
5-HT2a antagonist +++
NE reuptake inhibition
5-HT reuptake inhibition
- Scott
poster:SLS
thread:869924
URL: http://www.dr-bob.org/babble/20081223/msgs/870445.html