Posted by psychobot5000 on December 22, 2008, at 19:27:55
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl, posted by linkadge on December 22, 2008, at 14:05:59
> Again its hard to say. Activating the frontal cortex can actually supress certain limbic activity. I think there are probably subtle different neurobiological underpinnings of varients in OCD.
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> Do you mind me asking if your OCD is more classic (i.e. specific obsessions with associated specific behaviors indented to prevent the behaviors) or more ruminative?
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> Linkadge
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>Not at all, and thanks for all your thoughts. I suppose my personal OCD symptoms are mixed, including both behavioral and ruminative aspects--and both entangled with other anxiety symptoms. A bit of a mess, like many of us here, of course.
But, re 5HT2c and frontal cortex dopamine, I've decided to take some heart from the fact that stimulants (dexamph and methylphenidate) never made my OCD worse. So perhaps in my case increased stimulation of the frontal cortex would be fine, and there would be no conflict with improving executive function.
I didn't know that remeron/mirtazipine made some patients' OCD worse. Perhaps it's as you say, that Remeron only helps largely by reducing anxiety in-general (it did do that in my case). I wonder if ritanserin might have had similar beneficial effects on anxiety, without some of Remeron's drawbacks (sedation etc)--I suppose we'll never know). But with any luck, pharmacologists will get some helpful tools from the small slew of 5ht2 affecting meds in the pipeline.
Psychbot
poster:psychobot5000
thread:869924
URL: http://www.dr-bob.org/babble/20081214/msgs/870350.html