Posted by linkadge on December 22, 2008, at 20:55:59
In reply to Re: 5HT(2c), remeron and etc » linkadge, posted by psychobot5000 on December 22, 2008, at 19:27:55
Remeron has some opioid like effects. Opiates also have some anti-ocd effects.
Here's one study with ritanserin reversing some ocd effects of fluvoxamine.
http://www3.interscience.wiley.com/journal/109711247/abstract
A study demonstrating an upregulation of 5-ht2c receptors in OCD.
http://www.leaddiscovery.co.uk/articles/18533183
[Although, as mentioned, some 5-ht receptor antagonists also downregulate 5-ht receptors]
You've probably seen this article on psilocybin in OCD:
http://www.maps.org/research/psilo/azproto.html
There is a high density of 5-ht2a/c receptors in the caudate neucleus which acts as a gate between the frontal cortex and hypothalamus. OCD may be associated with less grey matter in this region to regulate crosstalk and that 5-ht receptor modulators somehow improve the functionality of this circuit.
Low doses of risperidal reduce OCD but higher doses increase it. Some effect on 5-ht2 receptor saturation?
http://www.springerlink.com/content/bdqt1fde2jqgf4h0/
Anyhow, there are only leads. There is nothing conclusive.Linkadge
poster:linkadge
thread:869924
URL: http://www.dr-bob.org/babble/20081214/msgs/870373.html