Posted by linkadge on December 22, 2008, at 14:05:59
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » linkadge, posted by psychobot5000 on December 22, 2008, at 10:56:32
>So is OCD thought to be related to frontal >cortex overactivity? (I have both OCD and severe >difficulty with executive function...so I'm very >curious...)
Generally yes, but it may depend on the nature of the OCD. If it is more rumanative, then there may not be frontal hyperactivity. If your OCD involves repetitive motor behaviors then perhaps this is associated with hyperactivity.
OCD and attention problems can certainly coexist and then it is probably more complex.
I do know that 5-ht1a receptor stimulation apparently has some anti-OCD effects. Remeron indirectly increases 5-ht1a receptor activity through the alpha-2 antagonism which may mediate some effects in OCD. I do know that in some studies potent and selective 5-ht2a/c antagonists can abololish or greatly reduce the anti OCD effects of SSRI's.
>It's worth mentioning, that (I read in one >article) some patients find Remeron (5HT2c >antagonist, no?) highly effective for OCD >symptoms. I also found this to be the case from >my personal experience.Remeron is not generally a first line OCD medication, but you are right there are case reports of it both improving (and worsening OCD). Remeron can have strong anxolytic effects which may indrectly improve OCD. Also, the enhanced 5-ht1a receptor stimulation could underly a theraputic effect in OCD.
>(and if frontal cortex activation is bad for >OCD...what is someone like myself with both OCD >and cognitive dysfunction/executive dysfunction >supposed to do, I wonder?)Again its hard to say. Activating the frontal cortex can actually supress certain limbic activity. I think there are probably subtle different neurobiological underpinnings of varients in OCD.
Do you mind me asking if your OCD is more classic (i.e. specific obsessions with associated specific behaviors indented to prevent the behaviors) or more ruminative?
Linkadge
poster:linkadge
thread:869924
URL: http://www.dr-bob.org/babble/20081214/msgs/870289.html