Posted by psychobot5000 on December 23, 2008, at 12:08:43
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » Marty, posted by SLS on December 23, 2008, at 7:16:15
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> To produce a treatment - whether monotherapy or polypharmacy - that will inhibit the reuptake of 5-HT and simultaneously antagonize 5-HT2a and 5-HT2c receptors in the absence of DA antagonism might be ideal to treat depression.
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> I hate when researchers feel it necessary to search for a single molecule that will combine all the relevant mechanisms of action. Just give us multiple drugs that are highly specific, complementary, and synergistic.
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> - ScottI agree (for what that's worth)--that would allow for more flexible and specific treatment for those of us who are resistant, while presumably also making drug development easier. However, I would suggest that almost any agent with significant serotonin reuptake inhibition would not be 'ideal,' (even assuming Linkadge is wrong and it -is- a significant AD mechanism), simply because the mechanism causes so many damned side-effects.
poster:psychobot5000
thread:869924
URL: http://www.dr-bob.org/babble/20081223/msgs/870489.html