Posted by desolationrower on December 22, 2008, at 12:32:52
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » linkadge, posted by psychobot5000 on December 22, 2008, at 10:56:32
IIRC 5ht2c also exhibits downregulation in the face of both agonism and antagonism. I think there was some evidence some of the psychedelics exhibit functional agonism at 5ht2a at least; my suspicion is that a number of drugs acting at ht52 receptors have these complicated actions; it woudl explain some of the contradictory findings. So i'd be quite wary of drawing conclusion of what one drug will do based on what another one does at this receptor. It doesn't seem this set of recptors is very well understood yet. lots of clues, not many real maps. Lots of info in this thread.
-d/r
poster:desolationrower
thread:869924
URL: http://www.dr-bob.org/babble/20081214/msgs/870281.html