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Re: +++ MAO-A or B ? Gerovital (procaine) selectivity

Posted by undopaminergic on July 6, 2008, at 2:47:33

In reply to Re: +++ MAO-A or B ? Gerovital (procaine) selectivity, posted by SLS on July 4, 2008, at 15:45:34

> > Clorgyline, similarly to selgiline, is subtype selective in low doses.
> I am not aware of a loss of selectivity at any dose. It is not like selegiline in this regard. It is specific (not selective) to MAO-A.

My impression is definitely that clorgyline affects MAO-B - insignificantly at low doses, but very much so at higher doses. I don't have any references at this time, but I know they exist.

To my knowledge, no perfectly specific MAO-inhibitors exist, although selegiline, rasagiline and clorgyline all have sufficient subtype-preference in order to be useful as research tools for clarifying the roles of the different types of MAO. As you suggest:

> Clorgyline is the most reliable probe specific to MAO-A and is the standard of reference by which MAO-A is assayed.
> - Scott




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