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Re: +++ MAO-A or B ? Gerovital (procaine) selectivity Marty

Posted by SLS on July 7, 2008, at 4:16:41

In reply to Re: +++ MAO-A or B ? Gerovital (procaine) selectivity SLS, posted by Marty on July 6, 2008, at 22:16:54

I will suggest to you what I suggested to Undopaminergic. If you are truly interested in knowing whether or not clorgyline is specific to MAO-A, do your own research. Look at more than one citation. You have not done so.

Yes, why is this important enough for YOU to argue about?

It seems to me that the dosages people arrive at when taking Emsam are above the lowest dose form. At this point, I am entertaining the notion that most people are responding to MAO-A inhibition. People responding to the low-dose oral form of selegiline as an adjunct might be benefiting more from its metabolites than from MAO-B inhibition. Again, though, most people using selegiline as monotherapy for depression generally take 10mg or more, which is beyond the threshold of selectivity.

By the way, I didn't need a lecture on the use of the two words "preferential" and "specific". I'm sure some authors will use the term "preferential" because they simply don't know any better. Also, if you would like to use logic of diction, "preferential" can designate a 100% bias. However, "specific" means no less than 100%. Right?

http://www.ncbi.nlm.nih.gov/pubmed/18463263?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

http://www.ncbi.nlm.nih.gov/pubmed/16157522?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

You might want to read my posts along this thread again. I grow weary of repeating myself.


- Scott


 

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