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Re: +++ MAO-A or B ? Gerovital (procaine) selectivity

Posted by SLS on July 4, 2008, at 15:45:34

In reply to Re: +++ MAO-A or B ? Gerovital (procaine) selectivity, posted by undopaminergic on July 4, 2008, at 13:36:27

> Clorgyline, similarly to selgiline, is subtype selective in low doses.

I am not aware of a loss of selectivity at any dose. It is not like selegiline in this regard. It is specific (not selective) to MAO-A. I would not yet presume additional mechanisms of action contributing to its antidepressant efficacy. Clorgyline is the most reliable probe specific to MAO-A and is the standard of reference by which MAO-A is assayed.

- Scott




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