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Re: --) Undopaminergic

Posted by undopaminergic on July 4, 2008, at 13:56:47

In reply to --) Undopaminergic, posted by Marty on July 4, 2008, at 9:44:24

> Hi,


> > It would be desirable to also inhibit COMT, an enzyme greatly contributing to extracellular destruction of all the cathecolamines, but unfortunately, the only central COMT inhibitor, tolcapone, has turned out to be rather hepatoxic.
> What about Entacapone (Comtan) ?

It's not hepatoxic, but it doesn't cross the blood-brain-barrier.

> What are you on Undopaminergic ?

For the depression, the most significant symptoms of which are anhedonia and lack of motivation (but my mood is OK), I mainly use methylphenidate and buprenorphine, usually augmented with sulpiride, and sometimes with rasagiline (formerly selegiline). I'm also taking guanfacine, pramiracetam (or aniracetam) and huperzine A for improving cognition and/or ADD symptoms. The next planned experiment is beta2-adrenergic agonists (e.g. Ventoline), probably in combination with L-dopa and other neurotransmitter precursors.




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