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Re: +++ MAO-A or B ? Gerovital (procaine) selectivity

Posted by SLS on July 9, 2008, at 4:26:02

In reply to Re: +++ MAO-A or B ? Gerovital (procaine) selectivity Marty, posted by SLS on July 7, 2008, at 4:16:41

More...

http://www.rxlist.com/cgi/generic/emsam_cp.htm

"Pharmacodynamics

Selegiline (the drug substance of EMSAM) is an irreversible inhibitor of monoamine oxidase (MAO), an intracellular enzyme associated with the outer membrane of mitochondria. MAO exists as two isoenzymes, referred to as MAO-A and MAO-B. Selegiline has a greater affinity for MAO-B, compared to MAO-A. However, at antidepressant doses, selegiline inhibits both isoenzymes (see below)."


- Scott

 

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