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--) Undopaminergic

Posted by Marty on July 4, 2008, at 9:44:24

In reply to Re: +++ MAO-A or B ? Gerovital (procaine) selectivity undopaminergic, posted by SLS on July 4, 2008, at 8:18:55


> It would be desirable to also inhibit COMT, an enzyme greatly contributing to extracellular destruction of all the cathecolamines, but unfortunately, the only central COMT inhibitor, tolcapone, has turned out to be rather hepatoxic.

What about Entacapone (Comtan) ?

>Regarding genes, reduced MAO-B activity has been associated with a diminished risk of Parkinson's disease, while reduced MAO-A activity is related to antisocial behaviour.

Interesting then that Nardil is the best med for Social Phobic: They have about 6x more chances of developing Parkinson's disease AND social avoidance, from a certain point of view, could be considered as being the opposite of antisocial behaviour (agressivity/confrontational).

>To the extent that reduced breakdown of trace amines (TAs) is of importance in the antidepressive effect of MAOIs, the B form of MAO is also the major - or exclusive - factor for some of the TAs, including phenylethylamine (PEA).

That's why I'm interested in trying low dose Selegeline. I think my mood is very sensitive PEA.. dark chococate lift my mood in a way that nothing else does, except Tianeptine. Espcially with dark chocolate with coffee chunks into it.. then it seems like I could use that as an AD on its own! interestingly coffee is a reversible MAO inhibitor .. Less MAO-B + More PEA seems like a good enough AD effect for me.

What are you on Undopaminergic ?





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