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Re: +++ MAO-A or B ? Gerovital (procaine) selectivity SLS

Posted by Marty on June 29, 2008, at 11:14:41

In reply to Re: +++ MAO-A or B ? Gerovital (procaine) selectivity Marty, posted by SLS on June 29, 2008, at 10:28:51

> MAO-A rules!

Hahaha.. what you meant is "MAO-A SUCKS!!"
just think about it... ;)

> I am trying to find the abstract on Medline >that I often come across regarding moclobemide >and dopaminergic neurotransmission, but there is >a property of this drug that reduces the tone of >dopamine neurons in certain regions of the brain >(I don't recall how).

Interesting. If you find it plz Babble Post me the link !

> That's right. A selective MAO-A inhibitor >*does* increase the levels of all three of the >monoamines thought to be involved with >depression: dopamine, norepinephrine, and >serotonin. There is no need to inhibit MAO-B.

Except if you want to elevate levels of some Phenethylamines which is my intent.

> I do not believe that a selective MAO-B
> inhibitor carries with it the same potency as a > MAO-A inhibitor.

I dont know about the potency, but MAO-Bs compose only 30% of all MAO in the brain. So 100% MAO-B inhibition equal only about 30% the raise of dopamine than 100% MAO-A inhibition. As you know it's an oversimplisistic way of seeing things but it gives us an idea anyway.

>That said, it seems that reversibility equates
> with inferior clinical effect.

Maybe, but what would I give to have my endogenous Reversible MAOI doing a better job (Tribulin/Isatin). .. that said Coffee could save my life for a couple hours. But it's arguable if it's because of its RIMA effect or Adenosine antagonistic effect. I would vote for the second as it act WAY faster.

SLS, I was wondering what you were doing in life .. you've been at the NIH as a patient or as a student/praticioner/searcher ?

Sometime I feel like going to one of those places and say "Attetion please people! I am Marty, I'm sick and I have a bunch of cool theories on which I have a lot of science to do in the next couple years. You've got 15 minutes to clear your respective labs office and exit my new research facility. Thank you!" :) ... my guess it's the only thing that would give me is the fastest "Narcissistic Personality Disorder" Dx in mankind history :P





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