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Re: selegiline delivery, Iansf Donna Louise

Posted by Jakeman on June 3, 2006, at 14:07:30

In reply to Re: rasagiline superior to selegiline? Iansf, posted by Donna Louise on June 3, 2006, at 6:18:07

From what I've read transdermal delivery has a much smoother dose response and more side effects are minimized. It's being absorbed over 24 hours rather than 5 minutes as would happen sublingually. And I suspect with putting drops under the tongue some of it may still go down the throat.

The dosing question has been a little confusing to me. My box of Emsam says: 20 mg (6mg/24h). I assume that means the patch contains 20 mg of selegiline, of which 6 mg is delivered to the body over 24 hours.
http://www.rxlist.com/cgi/generic4/emsam.htm

I mentioned in another thread that Squibb has a patient assistance program and Emsam is one the the drugs on the list.

Warm regards, Jake


> I am not Larry and this does not address your transdermal question, but the flaw in your idea may be that 6mg EMSAM is equal to 20mg of selegine. If 6 drops of sublingual is equal to 6mg (and I am not sure but I think it is) then you will not be getting the MAOI-A inhibiton, the type that allows for more serotonin. Of course, that may not be what you need and it would not matter. But for me, to treat the depression, it is looking like I will need at least 30mg of Selegiline (9mg patch). The lower doses will help raise NE and DA levels but not serotonin. I don't know anything about sublingual drops, if they come in a high enough mg to get at the serotonin.
>
> donna


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poster:Jakeman thread:649879
URL: http://www.dr-bob.org/babble/20060530/msgs/652403.html