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Re: rasagiline superior to selegiline? Iansf

Posted by Donna Louise on June 3, 2006, at 6:18:07

In reply to Re: rasagiline superior to selegiline? Larry Hoover, posted by Iansf on June 3, 2006, at 1:01:50

> Someone earlier challenged the idea that sublingual delivery bypassed the digestive system. He or she claimed it is not equivalent to transdermal delivery but rather the same as oral. Is that incorrect? I don't have enough information to know one way or the other, but I'm eager to find out. I cannot afford Emsam, but I could afford liquid selegiline. So if six drops (= to 6 mg) under the tongue works the same as a 6mg patch, I would be extremely happy.
> > It would be reasonable to assume that less of the noxious byproducts are formed, when transdermal is compared to oral. Sublingual *is* transdermal. Some of the thinnest dermis in your entire body is in your mouth and your nasal cavities. People snort drugs to take advantage of that. I wouldn't snort selegeline, but......
> >
> > How a person feels that reduction in byproduct production, is not within the bounds of my projective skill.
> >
> > Lar

I am not Larry and this does not address your transdermal question, but the flaw in your idea may be that 6mg EMSAM is equal to 20mg of selegine. If 6 drops of sublingual is equal to 6mg (and I am not sure but I think it is) then you will not be getting the MAOI-A inhibiton, the type that allows for more serotonin. Of course, that may not be what you need and it would not matter. But for me, to treat the depression, it is looking like I will need at least 30mg of Selegiline (9mg patch). The lower doses will help raise NE and DA levels but not serotonin. I don't know anything about sublingual drops, if they come in a high enough mg to get at the serotonin.





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