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Re: rasagiline superior to selegiline? Jakeman

Posted by Larry Hoover on May 31, 2006, at 21:37:47

In reply to Re: rasagiline superior to selegiline? Donna Louise, posted by Jakeman on May 31, 2006, at 21:34:27

> >
> > But see, one of the main advantages of the transdermal delivery system is that you don't get the same amount of amphetamine metabolites, even if they were toxic which I have not read that they are. So this may be true if you are talking about oral selegiline but it is probably no 'cleaner' than EMSAM.
> >
> > Donna
> Is that because the amphetamine metabolites are eliminated before they get to receptor sites? I was not clear on that from reading the emsam monographs (I have a weak to nil knowledge of biochemistry).
> BTW, where is Chairman MAO?
> warm regards, Jake

The amphetamines aren't formed in the same amounts in the first place, by bypassing the gut and liver first pass metabolism.





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