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Re: Codeine for Depression Treatment » Elizabeth

Posted by paulk on May 30, 2001, at 20:30:49

In reply to Re: Codeine for Depression Treatment, posted by Elizabeth on May 30, 2001, at 17:19:52

> > I’ve heard of this also about time-released addreal – There is a need but no one does it

>Adderal? That's a once-daily stimulant...why would there be a need for a slow-release formulation?

No, it’s not – usually used 2 – 3 times a day – a mixture of different half-life amphetamines – the idea is to have a tapering effect – (which makes no sense if it is used in multiple dosages???). Adderal used to be marketed under a different name for weight loss use. I tried it to overcome the memory problems I started having with Effexor with out good results. I got one day of good effect followed by a week of diminished returns – tried upping the dose – then a week of really nasty withdrawals.

It is also used for ADD – but Ritalin is generally preferred because of its longer half-life.

> > If that 1 is yourself it is always interesting. – How long has it been working for you – sounded like a some of the patients were only getting a few weeks worth of relief.

>That's a concern I've had, but it seems to be the exception rather than the rule. I've been taking it for about 6 months. (I had tried it before, a few years ago, but quit after a couple months because of side effects.)

> > >Demerol is atypical in that it's relatively excitatory compared with morphine.

> > Put me right to sleep.
>Demerol has a toxic metabolite (normeperidine) that's very proconvulsant. ("Excitatory" just means that it increases neuronal firing, BTW.)
It is a very big danger to anyone taking an MAOI. Single does have been fatal.

> > >Cocaine is a nonselective monoamine reuptake inhibitor (dopamine, norepinephrine, and serotonin). Medically, cocaine is used only as a local anaesthetic -- very different from systemic use as a psychostimulant.
> > I wonder if a slow release formula might be a good drug?

>Nomifensine -- an antidepressant that was withdrawn from the market about 15 years ago -- is a NE-DA reuptake inhibitor. It was supposed to be very effective, in particular for people who'd had no success with other ADs.

> > >Yes, some people have said they've successfully augmented ADs with naltrexone. That surprises me, since it's supposed to be a not-very-pleasant drug.
> > Didn’t bother me at all – per haps a bit of a headache the first day.

>It's variable, obviously. I would expect it to be neutral at best, tho'. It came as a huge surprise to hear that some people got an AD effect from it. (To my knowledge, it only works in combination with an AD, but even that was something I never would have guessed.)

I can only guess at the reasoning for it being a possible AD induced sex dysfunction remedy – perhaps some people get an endorphin response that could interfere with sex – makes some sense – orgasm produces lots of endorphin.




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