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Re: Codeine for Depression Treatment Elizabeth

Posted by paulk on May 30, 2001, at 11:00:53

In reply to Re: Codeine for Depression Treatment paulk, posted by Elizabeth on May 29, 2001, at 23:14:12

> >Very interesting - first time I have seen anything in print on this.

>That's because you don't read the professional journals.

Thanks for sharing it.

> > I would have to see a double blind study with a much higher N before I would get excited.

>Like I said -- no funding. The patents on existing opioids (including buprenorphine) have expired, so the drug companies have no motivation to fund such studies. The lack of acceptance of the idea on the part of the medical community makes it unlikely that new drugs will be developed for this purpose.

Ive heard of this also about time released addreal There is a need but no one does it

>But anyway, I got "excited" as soon as I found that it worked for me. For a person with TRD, n=1 is enough if they happen to be the 1 in question.

If that 1 is yourself it is always interesting. How long has it been working for you sounded like a some of the patients were only getting a few weeks worth of relief.

>Demerol is atypical in that it's relatively excitatory compared with morphine.

Put me right to sleep.

>Cocaine is a nonselective monoamine reuptake inhibitor (dopamine, norepinephrine, and serotonin). Medically, cocaine is used only as a local anaesthetic -- very different from systemic use as a psychostimulant.

I wonder if a slow release formula might be a good drug?

>Yes, some people have said they've successfully augmented ADs with naltrexone. That surprises me, since it's supposed to be a not-very-pleasant drug.

Didnt bother me at all per haps a bit of a headache the first day.


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