Psycho-Babble Medication | about biological treatments | Framed
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Re: Codeine for Depression Treatment

Posted by Elizabeth on May 30, 2001, at 17:19:52

In reply to Re: Codeine for Depression Treatment » Elizabeth, posted by paulk on May 30, 2001, at 11:00:53

> I’ve heard of this also about time released addreal – There is a need but no one does it

Adderal? That's a once-daily stimulant...why would there be a need for a slow-release formulation?

> If that 1 is yourself it is always interesting. – How long has it been working for you – sounded like a some of the patients were only getting a few weeks worth of relief.

That's a concern I've had, but it seems to be the exception rather than the rule. I've been taking it for about 6 months. (I had tried it before, a few years ago, but quit after a couple months because of side effects.)

> >Demerol is atypical in that it's relatively excitatory compared with morphine.
> Put me right to sleep.

Demerol has a toxic metabolite (normeperidine) that's very proconvulsant. ("Excitatory" just means that it increases neuronal firing, BTW.)

> >Cocaine is a nonselective monoamine reuptake inhibitor (dopamine, norepinephrine, and serotonin). Medically, cocaine is used only as a local anaesthetic -- very different from systemic use as a psychostimulant.
> I wonder if a slow release formula might be a good drug?

Nomifensine -- an antidepressant that was withdrawn from the market about 15 years ago -- is a NE-DA reuptake inhibitor. It was supposed to be very effective, in particular for people who'd had no success with other ADs.

> >Yes, some people have said they've successfully augmented ADs with naltrexone. That surprises me, since it's supposed to be a not-very-pleasant drug.
> Didn’t bother me at all – per haps a bit of a headache the first day.

It's variable, obviously. I would expect it to be neutral at best, tho'. It came as a huge surprise to hear that some people got an AD effect from it. (To my knowledge, it only works in combination with an AD, but even that was something I never would have guessed.)





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