Posted by Bob on May 21, 2010, at 20:03:53
In reply to Re: olanzapine vs. amitriptyline, posted by linkadge on May 20, 2010, at 18:36:27
> This is a good point about straterra and reboxetine. On paper, they look like better antidepressants than trimipramine but who knows.
>
> Here is an animal study in which olanzapine produced a faster onset of recovery from anhedonia than did amitriptyline. On paper, olanzapine is not an antidepressant, but in this study, it lead to a faster recovery of depressive symptoms than amitriptyline.
>
> http://www.ncbi.nlm.nih.gov/pubmed/15967060
>
> There are so many unknowns in the mechanisms of drug activity. There are so many targets for depression, HPA axis, neurotransimtters, neuromodulators, neurotrophic factors, circadian modulators, glutamate, substance p, galanin, neuropeptides, the list goes on.
>
> Parnate (a wonder drug for some) made me more depressed. Its so hard to know will work for any one individual.
>
> Linkadge
Which would you rather take if they were hypothetically of roughly equal therapeutic value? I understand that olanzapine has those pesky weight gain and diabetes problems, but the amitriptyline has weight gain too, and those super-pesky anti-cholinergic effects.
poster:Bob
thread:948075
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948242.html