Psycho-Babble Neurotransmitters | advanced medication issues | Framed
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Re: olanzapine vs. amitriptyline

Posted by linkadge on May 20, 2010, at 14:48:43 [reposted on May 20, 2010, at 18:36:27 | original URL]

In reply to Re: Gone with trimipramine, posted by SLS on May 20, 2010, at 6:26:16

This is a good point about straterra and reboxetine. On paper, they look like better antidepressants than trimipramine but who knows.

Here is an animal study in which olanzapine produced a faster onset of recovery from anhedonia than did amitriptyline. On paper, olanzapine is not an antidepressant, but in this study, it lead to a faster recovery of depressive symptoms than amitriptyline.

http://www.ncbi.nlm.nih.gov/pubmed/15967060

There are so many unknowns in the mechanisms of drug activity. There are so many targets for depression, HPA axis, neurotransimtters, neuromodulators, neurotrophic factors, circadian modulators, glutamate, substance p, galanin, neuropeptides, the list goes on.

Parnate (a wonder drug for some) made me more depressed. Its so hard to know will work for any one individual.

Linkadge


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URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948105.html